Laboratoire d'hématologie - Hôpital de la Timone

Recherches :

• Recherche translationnelle interfacée avec l’unité de recherche INSERM U608 sur les thèmes :
• Biomarqueurs endothéliaux et pathologies vasculaires
• Cellules souches endothéliales et médecine régénérative
• Dysfonction endothéliale en transplantation et pathologies rénales
• Transfert de technologie, innovation, valorisation

Publications :

• Ligi I, Simoncini S, Tellier E, Vassallo PF, Sabatier F, Guillet B, Lamy E, Sarlon G, Quemener C, Bikfalvi A, Marcelli M, Pascal A, Dizier B, Simeoni U, Dignat-George F, Anfosso F.A (2011 ). switch toward angiostatic gene expression impairs the angiogenic properties of endothelial progenitor cells in low birth weight preterm infants. Blood. 11,1699-709
• The sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin 1 (2011). Berda-Haddad Y,Robert S, Salers P, FArnarier C, Dinarello C, Dignat-George F and Kaplanski G. PNAS, in press
• Dignat-George F, Boulanger C. The many faces of endothelial microparticles. (2011) Arterioscler Thromb Vasc Biol, 31 : 27-33.
• K Harhouri, A Kebir, B Guillet, A Foucault-Bertaud, N Bardin, F Dignat-George, and M Blot- Chabaud.(2010) Soluble CD146 displays angiogenic properties and promotes therapeutic angiogenesis in experimental hind limb ischemia. Blood, 6, 1153843-51.
• Lacroix R., Robert S., Poncelet P., Kasthuri R.S., Key N.S., Dignat-George F. (2010).Standardization of platelet-derived microparticle enumeration by flow cytometry using calibrated beads: results of ISTH SSC Collaborative workshop. J Thromb Haemost, 8: 2571-4.
• Lacroix R, Robert S, Poncelet P and Dignat-George F.(2010) Overcoming limitations of measurement of microparticles by flow cytometry. Semin Thromb Hemost ; 36: 807-18
• Bonello L, Harhouri K, Sabatier F, Camoin-Jau L, Arnaud L, Baumstarck-Barrau K… Lesavre N, Paganelli F, Dignat-George F.(2010) Level of adenosine diphosphate receptor P2Y12 blockade during percutaneous coronary intervention predicts the extent of endothelial injury, assessed by circulating endothelial cell measurement. J Am Coll Cardiol. ;56:1024-31.
• Robert, S., Poncelet, P., Lacroix, R., Arnaud, L., Giraudo, L., Hauchard, A., Sampol, J., Dignat-George, F. (2009) Standardization of platelet-derived microparticle counting using calibrated beads and a Cytomics FC500 routine flow cytometer: a first step towards multicenter studies? J Thromb Haemost 7, 190-7.
• Sabatier, F., Camoin-Jau, L., Anfosso, F., Sampol, J., Dignat-George, F. (2009) Circulating endothelial cells, microparticles and progenitors: key players towards the definition of vascular competence. J Cell Mol Med 13, 454-71.
• Simoncini, S., Njock, M.S., Robert, S., Camoin-Jau, L., Sampol, J., Harle, J.R., Nguyen, C., Dignat-George, F., Anfosso, F. (2009) TRAIL/Apo2L mediates the release of procoagulant endothelial microparticles induced by thrombin in vitro: a potential mechanism linking inflammation and coagulation. Circ Res 104, 943-51.
• Jourde-Chiche, N., Dou, L., Sabatier, F., Calaf, R., Cerini, C., Robert, S., Camoin-Jau, L., Charpiot, P., Argiles, A., Dignat-George, F., Brunet, P. (2009) Levels of circulating endothelial progenitor cells are related to uremic toxins and vascular injury in hemodialysis patients. J Thromb Haemost 7, 1576-84.
• Al-Massarani, G., Vacher-Coponat, H., Paul, P., Arnaud, L., Loundou, A., Robert, S., Moal, V., Berland, Y., Dignat-George, F., Camoin-Jau, L. (2009) Kidney transplantation decreases the level and procoagulant activity of circulating microparticles. Am J Transplant 9, 550-7.
• Widemann, A., Sabatier, F., Arnaud, L., Bonello, L., Al-Massarani, G., Paganelli, F., Poncelet, P., Dignat-George, F. (2008) CD146-based immunomagnetic enrichment followed by multiparameter flow cytometry: a new approach to counting circulating endothelial cells. J Thromb Haemost 6, 869-76.
• Al-Massarani, G., Vacher-Coponat, H., Paul, P., Widemann, A., Arnaud, L., Loundou, A., Robert, S., Berland, Y., Dignat-George, F., Camoin-Jau, L. (2008) Impact of immunosuppressive treatment on endothelial biomarkers after kidney transplantation. Am J Transplant 8, 2360-7.
• Bonello, L., Camoin-Jau, L., Arques, S., Boyer, C., Panagides, D., Wittenberg, O., Simeoni, M.C., Barragan, P., Dignat-George, F., Paganelli, F. (2008) Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance: a multicenter randomized prospective study. J Am Coll Cardiol 51, 1404-11.
• Lacroix, R., Sabatier, F., Mialhe, A., Basire, A., Pannell, R., Borghi, H., Robert, S. Gurewich, V., Angles-Cano, E., Dignat-George, F. (2007) Activation of plasminogen into plasmin at the surface of endothelial microparticles: a mechanism that modulates angiogenic properties of endothelial progenitor cells in vitro. Blood 110, 2432-9.